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Drugs that enhance sexual function in men:

One of the phosphodiesterase 5 inhibitors, sildenafil was registered first, that initially it was not designed for the treatment of erectile dysfunction: This effect was discovered unexpectedly, like a "side effect". Tadalafil has been developed specifically for the treatment of erectile dysfunction, so of all the drugs that are on the market, it has the best effect in this group. Vardenafil (Levitra) - has an active substance that is very similar to sildenafil, so has the same effect. Only a few inhibitors are in development. Sildenafil inhibits phosphodiesterase phosphodiesterase 6 and 9; inhibition of phosphodiesterase 6 in the retina, is thought to be responsible for changes in vision, which can be a side effect of this drug. Likewise, tadalafil inhibits both PDE 5 and PDE 11, while on the vision it has no effect. These drugs are used to treat erectile dysfunction, they were the first effective oral medication, the available treatment for this condition. Due to the fact that PDE5 is also in the smooth muscle of arterial walls in the lungs, PDE5 inhibitors have also been investigated for their ability to treat hypertension in the pulmonary artery, a disease in which blood vessels in the lungs become abnormally narrow. These drugs increase the effectiveness of nitric oxide, which dilates the blood vessels of corpora cavernosa.

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Package Per item Price
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Cialis (Tadalafil)

Tadalafil - medication for the treatment of erectile dysfunction (inability to attain or maintain an erection necessary for sexual intercourse). Included in the group "Preparations for the treatment of erectile dysfunction".

Tadalafil is effective, reversible selective inhibitor of specific phosphodiesterase type 5 (PDE5), the cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 tadalafil leads to increased levels of cGMP in the cavernous body of the penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes erections. Tadalafil has no effect in the absence of sexual stimulation.

Cialis improves erection and the possibility of successful sexual intercourse. The drug acts during 36 hours. The effect appears even after 16 minutes after taking the drug in the presence of sexual arousal.

After oral administration of tadalafil is rapidly absorbed. The average maximum concentration (Cmax) in plasma is on average 2 hours after ingestion. The rate and extent of absorption of tadalafil are independent of food intake, so it may be taken without regard to meals. Hours (morning or evening) had no clinically significant effect on the rate and extent of absorption.

Tadalafil pharmacokinetics in healthy individuals is linear with respect to time and dose. At doses ranging from 2.5 to 20 mg of the area under the curve "concentration-timeĀ» (AUC) increases proportionally with dose. Equilibrium plasma concentration reached within 5 days while taking the drug once a day.

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